Understanding the fundamental biology of pathogens and their interactions with hosts and vectors underpins every aspect of infectious diseases research. The rise of antimicrobial resistant pathogens is one of the major challenges to global health. Delineating mechanisms of antimicrobial resistance (AMR), tracking AMR spread, discovering new antimicrobials, and exploring host-directed interventions will inform strategies for the control of multi-resistant pathogens.
- Pathogen and host genomics, physiology, and evolution
- Disease pathogenesis
- Host mechanisms of protection
- Discovery and characterisation of antimicrobial and antiparasitic leads
- Host-directed interventions
- Host-microbiome-interactions
- Vector biology
- One Health
Research outcomes and impact:
- Discoveries of pathogenesis mechanisms and targets for new interventions
- Characterising pathogens with pandemic potential, emerging pathogens, and zoonoses
- Uncovering mechanisms of antimicrobial resistance (AMR) and new interventions for AMR pathogens
- Defining host responses for improving diagnostics, prevention, and treatment